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Inhibiting SLIT-ROBO signalling decreases apoptosis as measured by an activated caspase-3/7 assay.

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posted on 20.02.2013, 11:21 by Rachel E. Dickinson, K. Scott Fegan, Xia Ren, Stephen G. Hillier, W. Colin Duncan

A) Treatment with the ROBO1/Fc chimera reduced caspase-3/7 activity, when compared to treatment PBS/0.1% (w/v) BSA (Control) in both PEO-14 and SKOV-3 cells. B) Transfection with SLIT2 siRNA reduced caspase-3/7 activity, when compared to treatment with a scrambled siRNA control. * = P<0.05.

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