Increased response to DSS treatment in the presence of only one allele of TC-PTP.
A. Increased weight loss of TC-PTP +/− mice during DSS-induced colitis. At 19 days of age mouse body weight was 11–12 g followed by DSS treatment. Body weight of DSS-treated TC-PTP +/− (Het-DSS) (2.58±0.4) mice were significantly lower than, TC-PTP+/− (Het) (5.0±0.8) and TC-PTP+/+ (WT-DSS) (3.78±0.5) mice ***p<0.0002. DSS-treated TC-PTP+/− mice compared to DSS-treated TC-PTP+/+ mice *p<0.001. Data represent the mean of three groups of three animals each (N = 9). B. Ratio of colon weight of DSS-treated TC-PTP +/− (Het-DSS) mice were significantly lower than DSS-treated TC-PTP+/+ (WT-DSS) mice p<0.05. In the case of TC-PTP+/− (Het) vs. DSS-treated TC-PTP+/− (WT-DSS) mice p<0.001, and p<0.001 in comparison of TC-PTP+/+ vs. DSS-treated TC-PTP+/+ mice.