In vivo muscle function of Actb-MNsKO mice.
(A) Grip strength, (B) treadmill, and (C) whole-body tension analysis performed on 6 and 12 month old control and Actb-MNsKO mice. n≥3 animals per genotype per time point for all experiments. No significant differences were observed between control and Actb-MNsKO mice in any assay at either time point. Error bars represent standard error of the mean. (D) Electromyography of 6 month old control and Actb-MNsKO mice showing no indication of fibrillation or fasciculation (n = 3 mice per genotype). Asterisks indicate depolarization due to initial needle insertion.