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In silico analyses revealed complex genomic architecture in regions of nonrecurrent rearrangement.

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posted on 21.02.2013, 07:09 by P. J. Hastings, Grzegorz Ira, James R. Lupski

(A) The ∼3 Mb surrounding the PLP1 gene and (B) the ∼4 Mb surrounding the MECP2 gene on the X chromosome contain numerous LCRs in various orientations [33],[106]. LCRs are represented by the colored block arrows, and like LCR copies are designated by color and letter for a given sequence. Orientation is depicted by the direction of the block arrow.