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Improvement of triad abnormalities present in Mtm1-deficient muscles with AAV-Mtm1-WT and AAV-Mtm1-CS.

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posted on 11.10.2012 by Leonela Amoasii, Dimitri L. Bertazzi, Hélène Tronchère, Karim Hnia, Gaëtan Chicanne, Bruno Rinaldi, Belinda S. Cowling, Arnaud Ferry, Bruno Klaholz, Bernard Payrastre, Jocelyn Laporte, Sylvie Friant

(A) Sarcomere and triad (arrowheads) organization in wild-type muscle, Mtm1 KO muscle, Mtm1 KO muscles injected with AAV-Mtm1-WT and AAV-Mtm1-CS at 2 different magnifications. Muscles from Mtm1 KO demonstrate a severe disorganization of the muscle fiber with lack of recognizable triads within the sarcomere structure. (B) Quantification of the presence of triads in the muscle fibers. The graph represents the ratio between the number of triads observed in each longitudinal section divided by the total number of sarcomeres present in the section. (C) Triads shape in wild-type muscle, and Mtm1 KO muscles injected with AAV-Mtm1-WT and AAV-Mtm1-CS.

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