Improved cardiac contractility in the PP-treated infarcted heart in a mouse model of myocardial infarction.
An effect of PP on cardiac function following myocardial infarction. Cardiac function following myocardial infarction was measured by echocardiography and shown as ejection-fraction (EF: %). The mice treated with vehicle (-PP) or PP (+PP) were subjected to echocardiography at days 1, 7 and 14 post sham-operation (Sham) or ligation (MI). The number of mice studied are as follows: Day 1: (Sham-PP: n=4; Sham+PP: n=3; MI-PP: n=17; MI+PP: n=20) Day 7: (Sham-PP: n=4; Sham+PP: n=3; MI-PP: n=17; MI+PP: n=20), Day 14: (Sham-PP: n=4; Sham+PP: n=3; MI-PP: n=11; MI+PP: n=14). ★p<0.05, ★★p<0.01. NS: not significant.