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Impact of myriocin and antifungal drugs on the Galleria mellonella hemograms.

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posted on 15.11.2013, 03:05 authored by Nadja Rodrigues de Melo, Ahmed Abdrahman, Carolyn Greig, Krishnendu Mukherjee, Catherine Thornton, Norman A. Ratcliffe, Andreas Vilcinskas, Tariq M. Butt

Hemocyte numbers (cells/ml) of G. mellonella larvae were determined 24 h after injection with C. albicans and/or drugs. The PBS group showed a significant increase in hemocyte numbers (*p<0.001, n = 20) and all the other groups showed a decrease of the hemocytes in comparison with control (CT). In particular, AMPH and MYR+AMPH groups showed decreased numbers (**p<0.001, n = 20). In all the groups where Candida was present, the hemocyte numbers were lower (***p<0.0001, n = 20). Controls were uninjected (CT) or PBS injected larvae. The drug treatments and abbreviations are as in Figure 1. Error bars indicate standard errors. Each experiment was triplicated.


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