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Impact of myriocin and antifungal drugs on phenoloxidase (PO) activity during Candida albicans pathogenesis.

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posted on 15.11.2013 by Nadja Rodrigues de Melo, Ahmed Abdrahman, Carolyn Greig, Krishnendu Mukherjee, Catherine Thornton, Norman A. Ratcliffe, Andreas Vilcinskas, Tariq M. Butt

The in vitro PO activity of G. mellonella larval hemolymph was measured at 24 h during fungal pathogenesis and drug treatments. Significant decreases of PO activity were detected in the groups treated with AMPH and MYR+FLC (*p<0.001, n = 10) when compared with the controls. In addition, all the treatments in which Candida was present, a significant decrease of PO activity was observed when compared with the control groups (**p<0.001, n = 10). However larvae from MYR+CA group showed higher PO activity (§ p<0.05) when compared with CA group alone. Controls were uninjected (CT) or PBS injected larvae. The drug treatments and abbreviations are as in Figure 1. Error bars indicate standard errors. Each experiment was triplicated.

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