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Immune response to different Aspergillus color mutants.

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posted on 18.02.2013, 02:14 by Lisa Rizzetto, Gloria Giovannini, Michael Bromley, Paul Bowyer, Luigina Romani, Duccio Cavalieri

Different mutant strains elicit diverse inflammatory responses and prime peculiar adaptive TH response. (A) DCs were cultured with UV-killed conidia or hyphae for 24 hours or without any stimuli (unstimulated, us) and supernatants were used for TNFα, IL-10, IL-1β, IL-6, IL-12p70 and IL-23 measurements. Data are represented as mean+SD (N = 6), *p≤0.05, **p≤0.01, conidial mutant strains vs conidial WT strain; §p≤0.05, §§p≤0.01, hyphal mutant strains vs hyphal WT strain. Complete statistically significant p-values are collected in Table S2. (B,C) Healthy PBMCs were cultured with live conidia or without any stimulus, and cytokine protein and transcript levels were measured. Data are represented as mean+SD (N = 6), *p≤0.05, **p≤0.01, mutants strain vs WT strain.