Illustration of EGFR degradation by CX-4945-induced authophagy.
Figures are generally photos, graphs and static images that would be represented in traditional pdf publications.
EGFR is delivered from the plasma membrane to early endosomes in endocytic vesicles. These vesicles are back to the plasma membrane through the recycling pathway. However, vesicles can also fuse with authophagosomes, and then directly with lysosomes leading to degradation of EGFR.