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Illustration of EGFR degradation by CX-4945-induced authophagy.

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posted on 08.12.2014 by Kwang Sup So, Cheol Hyeon Kim, Jin Kyung Rho, Sun Ye Kim, Yun Jung Choi, Joon Seon Song, Woo Sung Kim, Chang Min Choi, Young Jin Chun, Jae Cheol Lee

EGFR is delivered from the plasma membrane to early endosomes in endocytic vesicles. These vesicles are back to the plasma membrane through the recycling pathway. However, vesicles can also fuse with authophagosomes, and then directly with lysosomes leading to degradation of EGFR.

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