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Identification of Garcinol as a natural product biologically active on HSCs/PCs. A.

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posted on 12.09.2011, 01:57 by Taito Nishino, Changshan Wang, Makiko Mochizuki-Kashio, Mitsujiro Osawa, Hiromitsu Nakauchi, Atsushi Iwama

Experimental design for the screening of natural compounds acting on HSCs/PCs. B. Chemical structure of Garcinol and its derivatives. C. Garcinol expands CD34+CD38 cell numbers. hCB CD34+ cells were cultured in StemSpan SFEM medium with Garcinol or the same volume of DMSO (blank) in the presence of 20 ng/mL of hrTPO and 100 ng/mL of hrSCF. At day 7 of culture, the cells were analyzed by FACS for CD34 and CD38 expression (left panel). The numbers of CD34+CD38 cells relative to the blank are indicated [mean±standard error of the mean (SEM), n = 3]. *p<0.05.

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