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INa properties in control (CTRL) and heart failure (HF) rabbit ventricular myocytes assessed with alternating VC/CC, using the protocols shown in Figs. 1–5.

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posted on 2013-02-20, 21:31 authored by Géza Berecki, Ronald Wilders, Berend de Jonge, Antoni C. G. van Ginneken, Arie O. Verkerk

a, Typical examples of AP upstrokes (top) and their dV/dt's (bottom). b, Current-voltage relationships of the AP upstrokes. c, Dynamic INa activation curve with Boltzmann fits in solid lines. d, Steady-state voltage-dependence of inactivation with Boltzmann fits in solid lines. e, Recovery from inactivation with double-exponential fits in solid lines. f, Development of slow inactivation with double-exponential fits in solid lines.

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