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ING2 overexpression influences tadpole morphology upon T3 exposure.

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posted on 05.12.2011, 01:52 by Caren C. Helbing, Mary J. Wagner, Katherine Pettem, Jill Johnston, Rachel A. Heimeier, Nik Veldhoen, Frank R. Jirik, Yun-Bo Shi, Leon W. Browder

A) Comparison of morphological responses to T3 exposures of ING2-overexpressing tadpoles (TransING2, black bars; n = 20) and transgenic tadpoles expressing GFP only (TransGFP, white bars; n = 10). Vehicle control animals (C) are compared with tadpoles treated with 10 nM T3 for 5 days (T3). The asterisk denotes a significant difference between the TransING2 and the TransGFP transgenic animals (ANOVA, p<0.04; brain area: Mann Whitney U, p = 0.033). The “#” indicates statistical significance relative to the vehicle control within a transgenic type. The error bars represent the standard error of the mean. “Adjusted” data were corrected for the differences in body sizes by dividing the area values by the tail lengths before analysis of T3-dependent effects. B) Dorsal view of representative X. laevis tadpoles that were exposed to vehicle control (“C”) or T3 for 5 days. The black arrow indicates a more prominent protrusion of the lower jaw in the TransING2 animals compared to TransGFP transgenic animals.

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