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Hypoxia-pretreated BM-MSCs significantly increased the survival of the BM-MSCs in ischemic muscle, markedly increased angiogenesis and improved the proliferation of endothelial cells in ischemic muscle.
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posted on 2015-05-21, 03:34 authored by Jiejie Liu, Haojie Hao, Lei Xia, Dongdong Ti, Hong Huang, Liang Dong, Chuan Tong, Qian Hou, Yali Zhao, Huiling Liu, Xiaobing Fu, Weidong HanHypoxia-pretreated BM-MSCs significantly increased the survival of the BM-MSCs in ischemic muscle, markedly increased angiogenesis and improved the proliferation of endothelial cells in ischemic muscle.
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secrete angiogenic factorsrat bone marrow MSCstissue ischemiaBone Marrow Mesenchymal Stem Cells Facilitates AngiogenesisvegfHypoxia Pretreatmentoxygen concentrationsDLLI treatmentcell dysfunctionIschemia Endothelial dysfunctionpretreatedecexpression levelsDiabetic Ratsmultipotent secretory cellsunordered metabolism resultsangDouble immunofluorescence studiesEndothelial cellsmmp14 daystime periodslimb ischemiahifreconstruction challengesischemic muscle
