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Hyperactivation of the AMPK pathway in MLL-rearranged patients.

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posted on 21.10.2010, 00:54 by Benedetta Accordi, Virginia Espina, Marco Giordan, Amy VanMeter, Gloria Milani, Luisa Galla, Maria Ruzzene, Manuela Sciro, Luca Trentin, Ruggero De Maria, Geertruy te Kronnie, Emanuel Petricoin, Lance Liotta, Giuseppe Basso

(A) Histogram of proteins, that are part of the AMPK pathway, found to be differentially activated (Wilcoxon test with Benjamini-Hochberg multiplicity correction, p<0.05) between the MLL- and non-translocated cohorts. * indicates proteins that are part of the AMPK pathway, but that did reach statistical significance using Global Test analysis (p = 0.003). (B) Scheme of the AMPK pathway. (C) Heatmap with hierarchical clustering. The heatmap was generated with R Project using the proteins differentially expressed/phosphorylated in the “MLL-rearranged patients” group vs “non-translocated patients” group comparison. MLL-rearranged patients are highlighted in orange.