Hyperactivation of the AMPK pathway in MLL-rearranged patients.
(A) Histogram of proteins, that are part of the AMPK pathway, found to be differentially activated (Wilcoxon test with Benjamini-Hochberg multiplicity correction, p<0.05) between the MLL- and non-translocated cohorts. * indicates proteins that are part of the AMPK pathway, but that did reach statistical significance using Global Test analysis (p = 0.003). (B) Scheme of the AMPK pathway. (C) Heatmap with hierarchical clustering. The heatmap was generated with R Project using the proteins differentially expressed/phosphorylated in the “MLL-rearranged patients” group vs “non-translocated patients” group comparison. MLL-rearranged patients are highlighted in orange.