Human folate metabolism and hierarchical simplification into aggregate pools.
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(A) A map of the folate network described by . (B) An illustration of progressive pool formation across the first 4 time scales for the folate network based on the results from Figure 5. Beyond the first time scale pools form between CHF and CH2F; and 5MTHF, 10FTHF, SAM; and MET and SAH. DHF and THF form a pool beyond the second time scale. Beyond the third time scale CH2F/CHF join the 5MTHF/10FTHF/SAM pool. Beyond the fourth time scale HCY joins the MET/SAH pool. Ultimately, on time scales on the order of a minute and slower, interactions between the pools of folate carriers and methionine metabolites interact.