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Human AAT monotherapy during pancreatic islet xenotransplantation.

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posted on 22.05.2013, 01:42 by Efrat Ashkenazi, Boris M. Baranovski, Galit Shahaf, Eli C Lewis

Rat pancreatic islets were grafted into the renal subcapsular space of hyperglycemic mice. Recipients were treated with saline (CT) or human AAT throughout the experiment. (A) Islet graft survival curve (n = 6/group). (B) Graft histology. Representative day-seven explanted grafts from CT and hATT-monotreated mice (n = 3/group). Black arrows, remains of rat pancreatic islets. (C) Mouse gene expression at graft site. Grafts were explanted at indicated times after transplantation. Mean ± SEM from n = 3 grafts/group; *p<0.05, **p<0.01, ***p<0.001. (D) Rat gene expression at graft site. Grafts were explanted at indicated times after transplantation. Mean ± SEM from n = 3 grafts/group; **p<0.01.

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