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Homoisoflavanone SH-11052 inhibits proliferation of endothelial cells.

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posted on 2014-04-21, 10:09 authored by Halesha D. Basavarajappa, Bit Lee, Xiang Fei, Daesung Lim, Breedge Callaghan, Julie A. Mund, Jamie Case, Gangaraju Rajashekhar, Seung-Yong Seo, Timothy W. Corson

The effects of SH-11052 (2), an isomer of the natural-source homoisoflavanone 1 (A) on the proliferation of HUVECs (B) and HRECs (C) were tested by alamarBlue fluorescence in the concentration range of 0.5 nM to 500 µM and shown as mean ± SEM relative to DMSO control. Dose response curves and indicated GI50 values were generated using GraphPad Prism software.