Histopathological changes in the pathogenesis of hydrocephalus in the Ro1 model.
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Double-transgenic Ro1 mice and age-matched littermate controls were taken off dox at P30 and analyzed at 9 (n = 4), 12 (n = 7), 18 (n = 6), 24 (n = 6), 30 (n = 5) and 48 days (controls, n = 21; Ro1, n = 17) off dox to investigate histopathological changes in the pathogenesis of hydrocephalus in the Ro1 model. Images of coronal brain slices (A, D and G; scale bar = 1.0 mm), the dorsolateral wall of the left lateral ventricle (B, E and H; scale bar = 75 µm) and the aqueduct of Sylvius (C, F and I; scale bar = 50 µm) are shown from a control mouse (A–C; 24 days off dox) and two Ro1 mice (D–F and G–I, 24 and 48 days off dox, respectively). The Ro1 mice showed progressive enlargement of the lateral ventricles (D and G), thinning (E and H) of the ependymal layer of the lateral ventricles and disorganization of the ependymal lining of the aqueduct of Sylvius (F and I).