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Histopathological analysis and localization of CCR5+, CXCR3+, CCR4+, CCL5+ and CXCL9+ cells in heart tissue.

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posted on 2012-10-25, 00:50 authored by Luciana Gabriel Nogueira, Ronaldo Honorato Barros Santos, Barbara Maria Ianni, Alfredo Inácio Fiorelli, Eliane Conti Mairena, Luiz Alberto Benvenuti, Amanda Frade, Eduardo Donadi, Fabrício Dias, Bruno Saba, Hui-Tzu Lin Wang, Abilio Fragata, Marcelo Sampaio, Mario Hiroyuki Hirata, Paula Buck, Charles Mady, Edimar Alcides Bocchi, Noedir Antonio Stolf, Jorge Kalil, Edecio Cunha-Neto

Severe myocarditis with intense mononuclear inflammatory infiltrate in the heart tissues of CCC patient, and absence of myocarditis in the heart tissues of NIC patients and individuals without cardiomyopathies (N). In (A), imagens representative of heart fragments from CCC, NIC and N individuals. Haematoxylin-eosin stain. Representative images of immunofluorescence confocal microscopy from heart tissue sections from CCC and NIC (B). Sections were stained with primary antibodies against CCR5, CXCR3, CCR4, CCL5 and CXCL9 stained with AF633-conjugated anti-mouse IgG (red) and counterstained with DAPI (blue), as described in Methods. CTR- IgG isotype controls.