Histology of subcutaneous islet xenografts in immunocompetent diabetic mice.

A) Representative images of subcutaneously transplanted islets alone (ISC), PSI without cells and PSI containing: 10⁶ autologous fibroblasts (PSI-5F), 10⁶ allogenic BM-MSCs (PSI-5M), or 10⁶ of both autologous fibroblasts and allogenic BM-MSCs (PSI-5FM). Islet grafts were retrieved seven days after transplantation in diabetic mice. Samples were stained with H and E, or labelled with anti-insulin or anti-MPO antibodies. Black arrows point to islets. B) Quantification of the number of MPO-positive cells per field present on the leukocyte infiltration of the islet graft. C) Quantification of the insulin-positive area per section present on the islet graft. (**) p<0.01; (***) p<0.001.