Histological findings of orthotopic bone formation after treatment with various concentrations of SDF-1 with/without BMP2.
figureposted on 2015-03-17, 03:25 authored by Chang-Hwan Lee, Myoung Uk Jin, Hong-Moon Jung, Jung-Tae Lee, Tae-Geon Kwon
(A) Representative histological sections 4 weeks post-surgery (trichrome staining, ×40 in the box). (B) Bone formation ratio (%) and newly formed bone area (mm2) were analyzed histomorphometrically. Concomitant BMP-2 and SDF-1 treatment did not significantly activate orthotopic bone formation compared to independent treatment with BMP-2 or SDF-1 alone (*, p < 0.05).
Read the peer-reviewed publication
bone defectsvivo bone formationOrthotopic Bone Formation PurposesThetreatment alone.ConclusionsThese findingsbone marrowbone formationorthotopic bone regenerationsubcutaneous pockets4 weeksbmpmesenchymal cellscapillary tube formationosteoblastic differentiationorthotopic bone regeneration modelsDual TreatmentMethodsVarious dosesadditive effectradiographic density analysesrecruits mesenchymalC 57BL micecell migrationorthotopic bone formationcollagen spongesbone formation.Materialssdfmigration capacity