The intensity histogram of the whole-brain normalized FLAIR image in (A) the right hemisphere of patient #1, of which the semi-automatically demarcated WMHs volume was larger (7.954 ml), and (B) the left hemisphere of patient #20, of which the semi-automatically demarcated WMHs volume was smaller (0.736 ml). The demarcated WMHs in a slice is painted in yellow and shown in the inlet. The lowest bounds of the normalized intensity of the semi-automatically demarcated WMHs were both 65 in the hypothetical cerebral WM mask.