Hippocampal neuroanatomical changes induced by different intensities of exercise.
Effects of mild exercise (ME) or intense exercise (IE) on hippocampal DG volume (A), the number of Ki-67+ cells (marker of neuronal progenitor proliferation) (B), BrdU positive cells (marker of cell survival) (C) and BrdU+/NeuN+ cells (marker of newly generate matured neurons) (D). Representative photograph of the dentate gyrus (DG) from each group single-stained for Ki-67 (brown), or double-stained for BrdU (red) and NeuN (green) (E). Values are expressed as mean ± SE (n = 7). * p<0.05; ** p<0.01 compared to sedentary control (CONT) rats. There is no significant difference between both exercise groups in all items. Data were analyzed using a one-way ANOVA, followed by Tukey comparison post-hoc tests.