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Hippocampal neuroanatomical changes induced by different intensities of exercise.

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posted on 10.06.2015, 03:26 by Koshiro Inoue, Masahiro Okamoto, Junko Shibato, Min Chul Lee, Takashi Matsui, Randeep Rakwal, Hideaki Soya

Effects of mild exercise (ME) or intense exercise (IE) on hippocampal DG volume (A), the number of Ki-67+ cells (marker of neuronal progenitor proliferation) (B), BrdU positive cells (marker of cell survival) (C) and BrdU+/NeuN+ cells (marker of newly generate matured neurons) (D). Representative photograph of the dentate gyrus (DG) from each group single-stained for Ki-67 (brown), or double-stained for BrdU (red) and NeuN (green) (E). Values are expressed as mean ± SE (n = 7). * p<0.05; ** p<0.01 compared to sedentary control (CONT) rats. There is no significant difference between both exercise groups in all items. Data were analyzed using a one-way ANOVA, followed by Tukey comparison post-hoc tests.

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