High-frequency ultrasound imaging of targeted-microbubbles detects tumor vessel hypoxia.
figureposted on 2015-08-26, 03:55 authored by Nathan A. Koonce, Joseph Levy, Matthew E. Hardee, Azemat Jamshidi-Parsian, Kieng B. Vang, Sunil Sharma, James A. Raleigh, Ruud P. M. Dings, Robert J. Griffin
Representative image and quantified data of anti-pimonidazole labeled microbubbles (MBα-pimo) bound in perfused hypoxic tumor vasculature without pimonidazole injection (A), and with pimonidazole injection (B) in 4T1 tumor bearing mice. Top image shows the signal before the burst sequence and the bottom image shows after the burst sequence (A, B). (C) Quantified data of different experimental conditions using targeting and non-targeting microbubbles (as indicated). D) Summary of quantitated data statistically analyzed represented as mean ± SEM, #p < 0.05, versus non-targeting MB, MBα-pimo without pimonidazole injection, and MBα-pimo in muscle tissue (ANOVA post-hoc Holm-Sidak).
Read the peer-reviewed publication
Tumor Stromaltreatment efficacyUltrasound imagingSCKMouse modelsgland carcinoma modeltumor vessel hypoxiatumor oxygenation levelshypoxia marker pimonidazolemicroenvironmental conditionstreatment planning4 T 1tumor vessel hypoxia detectiontherapy resistanceprognostic capabilityMolecular Imagingtumor hypoxia detection methodsTumor Vascular Hypoxiasignal strengthTumor vasculaturetreatment outcomes