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H&E staining of pancreata from RARE-LacZ mice treated with caerulein (A), and subsequent recovery for 2 weeks (B), 4 weeks (C) and 6 weeks (D).

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posted on 29.12.2011 by Emily K. Colvin, Johana M. Susanto, James G. Kench, Vivienna N. Ong, Amanda Mawson, Mark Pinese, David K. Chang, Ilse Rooman, Sandra A. O'Toole, Davendra Segara, Elizabeth A. Musgrove, Robert L. Sutherland, Minoti V. Apte, Christopher J. Scarlett, Andrew V. Biankin

RA signalling activity in pancreata from RARE-LacZ mice treated with caerulein (E), and subsequent recovery for 2 weeks (F), 4 weeks (G) and 6 weeks (H). Increased retinoid signaling activity was observed in a significant proportion of acinar cells immediately following cessation of caerulein treatment (E), with retinoid activity peaking at 2 weeks (F), diminishing at 4 weeks (G) and returning to near normal levels following 6 weeks of recovery (H).

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