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Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytotoxicity Activities - Fig 1

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posted on 2015-07-22, 03:13 authored by Masaki Kurogochi, Masako Mori, Kenji Osumi, Mami Tojino, Shu-ichi Sugawara, Shou Takashima, Yuriko Hirose, Wataru Tsukimura, Mamoru Mizuno, Junko Amano, Akio Matsuda, Masahiro Tomita, Atsushi Takayanagi, Shin-Ichiro Shoda, Takashi Shirai

(A) Protocol of chemoenzymatic synthesis using ENG’ase and glycosynthase. (B) Diagram of the homogeneous glycosylated anti-Her2 mAb with M3 (mAb-M3), G0 (mAb-G0), G2 (mAb-G2), and A2 (mAb-A2).

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Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytotoxicity Activities
PLOS ONEPLOS ONE

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cell expression systemseng233QtypecdcSKBRIgG antibodiesFc γRIIIaadccbtantibody

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