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Genomic distribution of PR binding sites in T-47D and AB32 cells.

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posted on 24.04.2012 by Christine L. Clarke, J. Dinny Graham

Progestin-dependent PR bound DNA fragments identified by ChIP-seq were aligned to the genome using Bowtie and peaks of binding were identified using ERANGE, with 0.27% FDR. (A and B) Location of PR binding regions relative to transcription start sites of RefSeq genes in (A) T-47D and (B) AB32 cells was determined using CisGenome. (C and D) PR binding region distribution by chromosome, ranked by gene number in (C) T-47D and (D) AB32 cells. (E and F) Percentage of progestin regulated genes with PR binding regions within a given distance from the TSS in (E) T-47D and (F) AB32 cells. Solid line - binding regions associated with up-regulated genes, dashed line - binding regions associated with down regulated genes. The median distances of up- and down-regulated genes to nearest TSSs are indicated.

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