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Genome scan for the milk somatic cell count trait LSCS in a grand-daughter design of 1009 dairy sheep identifies a highly significant QTL on chromosome OAR3.

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posted on 2015-12-17, 08:08 authored by Rachel Rupp, Pavel Senin, Julien Sarry, Charlotte Allain, Christian Tasca, Laeticia Ligat, David Portes, Florent Woloszyn, Olivier Bouchez, Guillaume Tabouret, Mathieu Lebastard, Cécile Caubet, Gilles Foucras, Gwenola Tosser-Klopp

(A) Manhattan plot for likelihood ratio test profile for LSCS trait based on haplotype-based association analyses on the 26 ovine autosomes. (B) Global likelihood ratio test (LRT) profile for LSCS trait on chromosome OAR3 based on both linkage and haplotype-based association analyses. The 5% genome-wide thresholds are indicated for association (solid line) and linkage (dotted line) analyses. (C) Localisation of the 207 SNP in the OAR3 QTL confidence interval. SNP were identified using whole genome sequencing in a trio of rams.

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A Point Mutation in Suppressor of Cytokine Signalling 2 (Socs2) Increases the Susceptibility to Inflammation of the Mammary Gland while Associated with Higher Body Weight and Size and Higher Milk Production in a Sheep Model
PLOS GeneticsPLOS Genetics

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p.R 96C substitutionmastitiabrogates SOCS 2 binding affinitymilk leukocytes countJAKp.R 96C point mutationSNPpoint mutation causesgenome-wide association studies12 X coverageSCCSheep Model Mastitisovine chromosome 3. Fine mappingSocs 2 genotypeQTLSOCS 2SOCS 2 i.eSHsurface plasmon resonanceCytokine Signalling 2growth hormone receptor GHRmilk productionp.R 96C homozygote sheep

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