Genetic deletion studies to determine the role of GluK1 and GluK2 subunits in the KAR mediated current on the LIII mEC pyramidal neurons.
(A, B) By bath applying 300 nM KA, the holding current in the GluK1 KO did not change significantly when compared to the wild-type mice (p = 0.181; n = 4). However, no change in holding current was observed for GluK2 KO (n = 9) upon bath applying 300 nM KA indicating that the GluK2 is the predominant KAR subunit responsible for mediating the observed KAR current in these neurons. (A) Single experiment. (B) Group data.