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Gene expression comparison between C. albicans alone and drug-treated groups in Galleria mellonella.

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posted on 15.11.2013 by Nadja Rodrigues de Melo, Ahmed Abdrahman, Carolyn Greig, Krishnendu Mukherjee, Catherine Thornton, Norman A. Ratcliffe, Andreas Vilcinskas, Tariq M. Butt

Gene expression comparing C. albicans infected larvae group with and without antifungals. Expression of 17 gene transcripts in response to C. albicans and antifungal drugs 24 h post treatment. The value in each heat-map cell corresponds to the mean gene expression fold change relative to the uninjected larvae control (basal expression). To visualize the change in the gene expression a color gradient was used. The color gradients correspond to 3 different levels of gene expression relative to CA group. A light color represents low gene expression i.e.0–25% of that expressed by C. albicans alone; intermediate color to moderate gene expression i.e. 25%–50% of C. albicans alone; dark color to high gene expression, above 50% of C. albicans alone. The effect of MYR during Candida pathogenesis (MYR+CA group) in the Galleria larvae in comparison with CA group, showed a significant increase (*p<0.001) in the level of gene expression of 3 antimicrobial peptides GLIO, GVL and TSF, toll receptor 18W and stress related gene C1. On the other hand this treatment also caused a significant decrease of gene expression of IMPI, C5 (*p<0.001), C6 and C7 (**p<0.05). Abbreviations listed in Figure 7.

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