Gene expression comparison between C. albicans alone and drug-treated groups in Galleria mellonella.
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Gene expression comparing C. albicans infected larvae group with and without antifungals. Expression of 17 gene transcripts in response to C. albicans and antifungal drugs 24 h post treatment. The value in each heat-map cell corresponds to the mean gene expression fold change relative to the uninjected larvae control (basal expression). To visualize the change in the gene expression a color gradient was used. The color gradients correspond to 3 different levels of gene expression relative to CA group. A light color represents low gene expression i.e.0–25% of that expressed by C. albicans alone; intermediate color to moderate gene expression i.e. 25%–50% of C. albicans alone; dark color to high gene expression, above 50% of C. albicans alone. The effect of MYR during Candida pathogenesis (MYR+CA group) in the Galleria larvae in comparison with CA group, showed a significant increase (*p<0.001) in the level of gene expression of 3 antimicrobial peptides GLIO, GVL and TSF, toll receptor 18W and stress related gene C1. On the other hand this treatment also caused a significant decrease of gene expression of IMPI, C5 (*p<0.001), C6 and C7 (**p<0.05). Abbreviations listed in Figure 7.