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GRK2 is required for DEN2-NGC AND HCV propagation.

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posted on 13.09.2012 by Caroline Le Sommer, Nicholas J. Barrows, Shelton S. Bradrick, James L. Pearson, Mariano A. Garcia-Blanco

(A) Percentage of infected cells for HuH-7 transfected with control siRNAs or with siRNAs against GRK2, and infected with DEN2-NGC. The error bars represent the standard deviation of 10 wells. Statistical significance was tested using an ANOVA test, siRNAs with an inhibitory effect with a p-value<0.01 compared to siAllStars control are indicated by **. (B) Representative pictures of DEN2-NGC infection in GRK2−/−, bGRK2 and GRK2−/− MEFs at a magnification of 10× with the nuclei staining in blue and the viral staining in green. (C) Percentage of infected cells for GRK2−/−, bGRK2, GRK2−/−, GRK6+/+, and GRK6−/− MEFs. The error bars represent the standard deviation of at least 4 wells. Statistical significance was tested using Welch's t-test, conditions with an inhibitory effect with a p-value<0.05 or <0.01 compared to control are indicated by * or ** respectively. (D) Percentage of infected cells for HuH-7.5 transfected with control siRNAs or with siRNAs against GRK2, and infected with HCV. The error bars represent the standard deviation of 10 wells. Statistical significance was tested using an ANOVA test, siRNAs with an inhibitory effect with a p-value<0.01 compared to siAllStars control are indicatedby **.

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