Functional classes of mRNAs associate with strain dependent changes.
Genes involved in (A) surfactant homeostasis and (B) innate defense were expressed at significantly higher levels in B6 than in A/J mice at E18.5. (C) Histone associated genes and (D) genes involved in chromatin assembly/disassembly were expressed at significantly lower levels in B6 than in A/J mice at E18.5. (E) RT-PCR validation of selected mRNAs encoding chromatin regulators in lungs from B6 and A/J mice at E18.5 is shown. Results are expressed as the means ± SEM of 3 animals per time point.