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Forest plot of the effect of the interaction between the FTO rs9939609 SNP and physical activity on BMI in a random effects meta-analysis of 218,166 adults.

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posted on 2011-11-01, 02:08 authored by Tuomas O. Kilpeläinen, Lu Qi, Soren Brage, Stephen J. Sharp, Emily Sonestedt, Ellen Demerath, Tariq Ahmad, Samia Mora, Marika Kaakinen, Camilla Helene Sandholt, Christina Holzapfel, Christine S. Autenrieth, Elina Hyppönen, Stéphane Cauchi, Meian He, Zoltan Kutalik, Meena Kumari, Alena Stančáková, Karina Meidtner, Beverley Balkau, Jonathan T. Tan, Massimo Mangino, Nicholas J. Timpson, Yiqing Song, M. Carola Zillikens, Kathleen A. Jablonski, Melissa E. Garcia, Stefan Johansson, Jennifer L. Bragg-Gresham, Ying Wu, Jana V. van Vliet-Ostaptchouk, N. Charlotte Onland-Moret, Esther Zimmermann, Natalia V. Rivera, Toshiko Tanaka, Heather M. Stringham, Günther Silbernagel, Stavroula Kanoni, Mary F. Feitosa, Soren Snitker, Jonatan R. Ruiz, Jeffery Metter, Maria Teresa Martinez Larrad, Mustafa Atalay, Maarit Hakanen, Najaf Amin, Christine Cavalcanti-Proença, Anders Grøntved, Göran Hallmans, John-Olov Jansson, Johanna Kuusisto, Mika Kähönen, Pamela L. Lutsey, John J. Nolan, Luigi Palla, Oluf Pedersen, Louis Pérusse, Frida Renström, Robert A. Scott, Dmitry Shungin, Ulla Sovio, Tuija H. Tammelin, Tapani Rönnemaa, Timo A. Lakka, Matti Uusitupa, Manuel Serrano Rios, Luigi Ferrucci, Claude Bouchard, Aline Meirhaeghe, Mao Fu, Mark Walker, Ingrid B. Borecki, George V. Dedoussis, Andreas Fritsche, Claes Ohlsson, Michael Boehnke, Stefania Bandinelli, Cornelia M. van Duijn, Shah Ebrahim, Debbie A. Lawlor, Vilmundur Gudnason, Tamara B. Harris, Thorkild I. A. Sørensen, Karen L. Mohlke, Albert Hofman, André G. Uitterlinden, Jaakko Tuomilehto, Terho Lehtimäki, Olli Raitakari, Bo Isomaa, Pål R. Njølstad, Jose C. Florez, Simin Liu, Andy Ness, Timothy D. Spector, E. Shyong Tai, Philippe Froguel, Heiner Boeing, Markku Laakso, Michael Marmot, Sven Bergmann, Chris Power, Kay-Tee Khaw, Daniel Chasman, Paul Ridker, Torben Hansen, Keri L. Monda, Thomas Illig, Marjo-Riitta Järvelin, Nicholas J. Wareham, Frank B. Hu, Leif C. Groop, Marju Orho-Melander, Ulf Ekelund, Paul W. Franks, Ruth J. F. Loos

The studies are sorted by sample size (largest sample size lowest). Details of the studies are given in Text S1. The interaction beta represents the difference in BMI per minor (A−) allele of rs9939609 comparing physically active individuals to inactive individuals, adjusting for age and sex. For example, a betainteraction of −0.10 kg/m2 for BMI represents a 0.10 kg/m2 attenuation in the BMI-increasing effect of the rs9939609 minor allele in physically active individuals compared to inactive individuals.

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