Forest plot of the effect of the interaction between the FTO rs9939609 SNP and physical activity on BMI in a random effects meta-analysis of 218,166 adults.
The studies are sorted by sample size (largest sample size lowest). Details of the studies are given in Text S1. The interaction beta represents the difference in BMI per minor (A−) allele of rs9939609 comparing physically active individuals to inactive individuals, adjusting for age and sex. For example, a betainteraction of −0.10 kg/m2 for BMI represents a 0.10 kg/m2 attenuation in the BMI-increasing effect of the rs9939609 minor allele in physically active individuals compared to inactive individuals.