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Fitting of the experimental I(t) (open circles) using a scenario that combines increased particle availability (J>0) and fork-density dependent affinity: P(NB(t)) = P0+P1[1−exp(−NB(t)/Nc)] and NC = 7×103.

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posted on 21.02.2013, 09:53 by Arach Goldar, Hélène Labit, Kathrin Marheineke, Olivier Hyrien

The solid black line is the best fit to the increasing part of the data using a Levenberg-Marquardt algorithm coupled with a dynamic Monte Carlo method (P0 = 10−4 kb−1 s−1, P1 = 2×10−3 kb−1 s−1, J = 5 s−1and N0 = 1000; χ2 = 10−9). Blue and red curves represent the simulated replicated fraction and the fork density, respectively.