Fischer F344 rats have increased ethanol consumption and preference using the intermittent access to 20% ethanol procedure.
Escalation of 20% ethanol (A) consumption and (C-D) preference in F344 rats using the intermittent access to 20% ethanol (IAE) procedure. Animals were divided into groups of high-drinkers (n = 12) and low drinkers (n = 12) with the high group exhibiting significantly higher ethanol consumption. (C) Ethanol preference for the combined high and low drinkers trained on the IAE procedure. F344 rats on a 20% ethanol continuous-access (CA) schedule showed no significant difference between high and low groups for (B) consumption or (E) preference and no significant escalation for either measure overall. The values are expressed as mean ethanol intake (g ( kg ( 24 h) or preference (ratio of ethanol over total fluid intake) ± SEM at each drinking session. *p< 0.05, **p<0.01, and ***p<0.001 comparing the two groups (two-way repeated measures ANOVA followed by Newman–Keuls post hoc test).