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Fas activation in THP-1-derived macrophages does not induce caspase 3/7 activation.

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posted on 2015-04-07, 03:01 authored by Caitriona Lyons, Philana Fernandes, Liam J. Fanning, Aileen Houston, Elizabeth Brint

THP-1-derived macrophages and Jurkat T cells were treated with 100 ng/ml CH11 and/or 20 μg/ml poly I:C for 24 hrs, or with 5 μM staurosporine as indicated. Both caspase 3/7 activation (A) and cell viability (B) were determined after 24 hrs by fluorescence and trypan blue, respectively. Data shown are representative of three independent experiments, with values shown as Mean ± SEM.