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FTO gene structure, and LD pattern between all pairs of genotyped SNPs.

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posted on 27.05.2011, 00:09 by Josefin A. Jacobsson, Markus Sällman Almén, Christian Benedict, Lilia A. Hedberg, Karl Michaëlsson, Samantha Brooks, Joel Kullberg, Tomas Axelsson, Lars Johansson, Håkan Ahlström, Robert Fredriksson, Lars Lind, Helgi B. Schiöth

The black triangles indicate haplotype blocks defined by confidence interval according to Gabriel et al. (Gabriel et al.). The diamonds represent the pair-wise linkage disequilibrium (LD) indicated as r2 (black r2>0.8, dark gray 0.5–0.8, moderate gray 0.4–0.6, light gray 0.2–0.4 and white r2<0.2). Each line represents a SNP. A) LD pattern and haplotype blocks based on the PIVUS data B) LD pattern and haplotype blocks based on HapMap data (version 3, release 27 and CEU+TSI). Only genotyped markers and haplotypes with a frequency >1% are included. The Haplotype analysis was performed using Haploview 4.1.