Fig_5.tif (4.73 MB)

Extracellular matrix deposition was evident in TEVG over the course of the 12-month experiment.

Download (0 kB)
posted on 01.04.2015 by Hirotsugu Kurobe, Mark W. Maxfield, Shuhei Tara, Kevin A. Rocco, Paul S. Bagi, Tai Yi, Brooks Udelsman, Zhen W. Zhuang, Muriel Cleary, Yasuko Iwakiri, Christopher K. Breuer, Toshiharu Shinoka

A. Histologic analysis of graft tissue testing for elastin (EVG: Elastica van Giesen), collagen, elastic and cellular architecture (Movat’s and Masson trichrome) (n = 5 in each group). There is minimal elastin within the graft as compared to that that seen in native aorta. There is presence of endothelial and adventitial cells of the grafts with neo-collagen containing extracellular matrix. B. Expression of extracellular matrix components (n = 5–10 in each group). SMC, a marker of smooth muscle cells. Data were normalized using hypoxanthine-guanine phosphoribosyltransferase (HPRT).