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Expression profile of androgen-responsive genes in PC346 cells linked to publicly available databases on AR transcriptional regulation.

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posted on 04.08.2011, 02:32 authored by Rute B. Marques, Natasja F. Dits, Sigrun Erkens-Schulze, Wilfred F. J. van IJcken, Wytske M. van Weerden, Guido Jenster

On the left side, PC346C, PC346Flu1 and PC34Flu2 were exposed to 1 nM R1881 or 1 µM OH-flutamide for 4, 8 and 16h, whereas PC346DCC was stimulated with 1 nM R1881 only. On the right side, our gene signature was assessed in the databases from DePrimo et al., Nelson et al., Nickols et al., Wang et al. and Hendriksen et al. (see Table 7 for database details). Heat-map is presented for the 2log expression ratio between hormone-treated samples and respective time-matched vehicle controls. Red and green colors represent induction and repression, respectively, whereas black indicates no regulation. Grey squares indicate missing data due to low expression, poor data quality or absence of probes for the respective transcript in the array platform used for the study.