Expression of cellular markers of CH in normotensive- and pre-hypertensive Milan rats.
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Studies were performed in normotensive (MNS) and pre-hypertensive (MHS-pre) Milan rats at 30 days of age. Each bar represents the mean ± s.e.m., n = 6 animals in each group. A) Body weight; B) Left ventricular (LV) weight/body weight (BW) ratio; C) Systolic blood pressure (SBP); D) Brain natriuretic peptide (NPPB) mRNA expression levels; E) β-myosin heavy chain (β-MHC) mRNA expression levels; F) α-myosin heavy chain (α-MHC) mRNA expression levels; G) Representative hematoxylin and eosin stained cross-sections from the left ventricle MNS and MHS-pre rats. Bar: 50 µm; H) Expression levels of mRNA for SIK isoforms.