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Exposure to PVC flooring increases acute airway inflammation, antigen-specific IgE and Th2 cytokine levels and reduced IFN-γ production in OVA-sensitized Balb/c mice.

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posted on 03.07.2012, 01:14 by Ulrike Bönisch, Alexander Böhme, Tibor Kohajda, Iljana Mögel, Nicole Schütze, Martin von Bergen, Jan C. Simon, Irina Lehmann, Tobias Polte

Balb/c mice were immunized with OVA (day 1 and 14) and then challenged with OVA on days 14 and 17–19. Mice were exposed to PVC flooring from day 0 to day 20. Effect of PVC flooring on inflammation (H&E, x200, A), verified by an objective, investigator-independent computer-based quantification of lung inflammation (B), on total cell numbers in the BAL fluid (C), OVA-specific IgE levels (D), lung resistance (E), lung compliance (F) and Th2 cytokine levels in the supernatant of OVA-re-stimulated splenocytes (G) or mediastinal lymphnodes (H). Data are expressed as mean ± SEM, n ≥ 9 animals per group; *p<0.05 vs. OVA.

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