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Experimental protocols of thioacetamide (TAA)-induced hepatic fibrosis in rats pretreated with Sho-Saiko-To (SST).

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posted on 09.12.2014, 02:55 by Ya-Wen Chen, Meng-Yuan Tsai, Huay-Ben Pan, Hui-Hwa Tseng, Yu-Ting Hung, Chen-Pin Chou

Eight-week-old male rats were intraperitoneally injected with TAA (200 mg/kg) twice weekly at weeks 1 and 2 and then once at weeks 5 and 6. A cohort of rats receiving vehicle without treatment of SST (TAA only) was assigned as Group 1. Group 2 (TAA +0.25 g/kg SST) was administered moderate dose (0.25 g/kg) of SST two days before the first TAA exposure and sustained for 6 weeks. Group 3 (TAA +1 g/kg SST) was administered high dose (1 g/kg) of SST.