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Experience-dependent CaMKIIα phosphorylation in the hippocampus during REM.

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posted on 28.05.2015, 03:58 by Wilfredo Blanco, Catia M. Pereira, Vinicius R. Cota, Annie C. Souza, César Rennó-Costa, Sharlene Santos, Gabriella Dias, Ana M. G. Guerreiro, Adriano B. L. Tort, Adrião D. Neto, Sidarta Ribeiro

(A) Normalized hippocampal levels of pCaMKIIα, total CaMKIIα, Zif-268 and Actin (mean densitometric levels, one datapoint per animal). Kruskal-Wallis followed by Dunn’s test between consecutive states revealed a significant increase from SWS to REM (*p<0.05). Normalized levels of total CaMKIIα, Zif-268 and Actin in the hippocampus were not significantly different across states. This was expected because of the slower regulation kinetics of these proteins, in comparison with pCaMKIIα. Numbers on the bottom indicate the curvatures of the quadratic fits in red. (B) Schematic representation of the theoretical predictions for levels of plasticity markers across wake-sleep states. Compare with the quadratic fits on panel A.