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Exogenous NE stimulates proliferation of hHSC.

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posted on 03.09.2013 by Barbara Sigala, Chad McKee, Junpei Soeda, Valerio Pazienza, Maelle Morgan, Ching-I Lin, Clare Selden, Sara Vander Borght, Gianluigi Mazzoccoli, Tania Roskams, Manlio Vinciguerra, Jude A. Oben

a) NE induced a dose-dependent, biphasic, enhancement of proliferation of hHSC, with a maximal effect at 10 nM. Each bar represents mean ± SEM of triplicate responses in one typical experiment, expressed as a percentage of the response in serum free control wells. Similar results have been obtained on at least three other occasions; SF, serum free; * p<0.001, ** p<0.0001. b) Phase contrast micrographs are shown as visual confirmation of actual cell number increase in the presence of increasing concentrations of NE.