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Exogenous NE induced collagen expression through TGF-β.

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posted on 03.09.2013 by Barbara Sigala, Chad McKee, Junpei Soeda, Valerio Pazienza, Maelle Morgan, Ching-I Lin, Clare Selden, Sara Vander Borght, Gianluigi Mazzoccoli, Tania Roskams, Manlio Vinciguerra, Jude A. Oben

a) NE upwards of 10nM significantly increased hHSC collagen-1a2 gene expression, with absence of serum and TGF-β as negative and positive controls. b) NE significantly induced expression TGF-β. Results (mean ±SEM of triplicate responses in one typical experiment) are expressed as a percentage of the response in serum free control wells, vs SF, *p<0.05. Similar results have been obtained on at least three other occasions.