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Exogenous NE and EPI stimulate proliferation of hHSC through p38 MAP, PI3K and MEK.

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posted on 03.09.2013 by Barbara Sigala, Chad McKee, Junpei Soeda, Valerio Pazienza, Maelle Morgan, Ching-I Lin, Clare Selden, Sara Vander Borght, Gianluigi Mazzoccoli, Tania Roskams, Manlio Vinciguerra, Jude A. Oben

a) Pre-treatment for 2 hours with PT (G-protein inhibitor, 100 nM) and SB203580 (p38MAP inhibitor, 10 µM) significantly reduced NE induced hHSC proliferation, with WT wortmannin (PI3K inhibitor, 100 nM), and PD98059 (MEK inhibitor, 100 nM) also slightly but non-significantly reducing NE-induced proliferation. b) The proliferative effects of EPI were also inhibited by PT and furthermore by WT, PD and RO (PKC inhibitor, 1 µM).