Exogenous EPI stimulate proliferation of hHSC.
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a) EPI, as with NE, similarly induced proliferation of cultured activated hHSC, at EPI concentrations of 1 nM–1 µM with a maximal effect at 10 nM. b) Prazosin (10 µM) significantly inhibited NE induced hHSC proliferation. PRL (10 µM) also inhibited EPI induced hHSC proliferation. Results are expressed as a percentage of each agonist control (100%).