Example of the spatially highly resolved DCE-MRI that was used as estimation data, showing the pre-contrast acquisition (panel A), followed by the post-contrast acquisitions (panels B–G) with a distinct accumulation of the contrast agent in the liver. The dark areas within the liver in the late phases (panels D–G) are mainly blood vessels with drastically lower concentration of contrast agent compared to the accumulated contrast agent in the hepatocytes. This difference can be appreciated quantitatively in panel H, since the increase in signal intensity in the spleen is only due to the CA residing within the blood plasma. The location of the seven different regions of interest placed in the liver are shown throughout the time series (panels A–G, one in each panel), indicated by the red arrow heads. The hepatic artery, with a high initial concentration of contrast, can be seen in panel B (red arrow) as well as the portal vein (blue double arrow). In panel C the spleen (orange open arrow head) is almost isointense with the liver. The efflux of CA in the common bile duct can be seen in panel D (green arrow). Finally, the quantified mean relative change in relaxivity in the ROIs placed in the liver and spleen throughout the examination is shown in panel H, with the vertical bars corresponding to the standard error of the mean.