Epigenetic landscape is defined by <i>HDM</i>/<i>HMT</i> gene expression signature.

<p>The status of <i>HDM</i> and <i>HMT</i> gene expression is presented in red (higher expression) and green (lower expression) colors. The KDM5A, EZH2, H3K4me3 and H3K27me3 modules are shown as large circles, either preferentially expressed (in red color) or underexpressed (in blue color). The expression of KDM5A targets and genes with H3K4me3 is determined by the levels of <i>HDM1</i> and <i>HMT1</i>, which are relatively high in blood cells. In leukemia cells, the level of <i>HMT1</i> becomes lower, the level of <i>HDM2</i> becomes higher and as a result, the responsive H3K4me3 module is not preferentially expressed anymore. Some of the H3K4 and H3K27 trimethylated regions overlap as bivalent marks and remain poised for expression (shown as a grey area in the overlap).</p>